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  2. Potassium channel blocker - Wikipedia

    en.wikipedia.org/wiki/Potassium_channel_blocker

    Class III agents predominantly block the potassium channels, thereby prolonging repolarization. [2] More specifically, their primary effect is on I Kr. [3] Since these agents do not affect the sodium channel, conduction velocity is not decreased. The prolongation of the action potential duration and refractory period, combined with the ...

  3. Depolarization - Wikipedia

    en.wikipedia.org/wiki/Depolarization

    The process of repolarization causes an overshoot in the potential of the cell. Potassium ions continue to move out of the axon so much that the resting potential is exceeded and the new cell potential becomes more negative than the resting potential. The resting potential is ultimately re-established by the closing of all voltage-gated ion ...

  4. Repolarization - Wikipedia

    en.wikipedia.org/wiki/Repolarization

    A labeled diagram of an action potential.As seen above, repolarization takes place just after the peak of the action potential, when K + ions rush out of the cell.. In neuroscience, repolarization refers to the change in membrane potential that returns it to a negative value just after the depolarization phase of an action potential which has changed the membrane potential to a positive value.

  5. Dendrotoxin - Wikipedia

    en.wikipedia.org/wiki/Dendrotoxin

    Dendrotoxins have been shown to block particular subtypes of voltage-gated potassium (K +) channels in neuronal tissue. [1] In the nervous system, voltage-gated K + channels control the excitability of nerves and muscles by controlling the resting membrane potential and by repolarizing the membrane during action potentials .

  6. Potassium channel - Wikipedia

    en.wikipedia.org/wiki/Potassium_channel

    final repolarization phase and stabilising the resting potential of the action potential in cardiac ... Barium ions can also block potassium channel currents, [88] ...

  7. Azimilide - Wikipedia

    en.wikipedia.org/wiki/Azimilide

    This block exhibits reverse use-dependence, i.e. the channel blocking effect wanes at faster pulsing rates of the cell. A possible explanation is an interaction of azimilide with K + close to its binding site in the ion channel. However, there is an agonist effect as well, which is a voltage-dependent effect.

  8. End-plate potential - Wikipedia

    en.wikipedia.org/wiki/End-plate_potential

    During repolarization, the sodium channels begin to become inactivated, causing a net efflux of potassium ions. This causes the membrane potential to drop down to its resting membrane potential of -100mV. Hyperpolarization occurs because the slow-acting potassium channels take longer to deactivate, so the membrane overshoots the resting ...

  9. Action potential - Wikipedia

    en.wikipedia.org/wiki/Action_potential

    After the action potential peak is reached, the neuron begins repolarization (3), where the sodium channels close and potassium channels open, allowing potassium ions to cross the membrane into the extracellular fluid, returning the membrane potential to a negative value.