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Normal vaginal mucosa (left) versus vaginal atrophy (right) Specialty: Gynecology: Symptoms: Pain with sex, vaginal itchiness or dryness, an urge to urinate [1] Complications: Urinary tract infections [1] Duration: Long term [1] Causes: Lack of estrogen [1] Risk factors: Menopause, breastfeeding, certain medications [1] Diagnostic method: Based ...
Treatment: A couple of options for treating menopause-related dryness are prescription local vaginal estrogen pills, creams, or rings. There are also non-hormonal options such as DHEA and the CO2 ...
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It may have a decreased risk of breast and colorectal cancer, though conversely it can be associated with vaginal bleeding, endometrial cancer, and increase the risk of stroke in women over age 60 years. [127] [128] Vaginal estrogen can improve local atrophy and dryness, with fewer systemic effects than estrogens delivered by other routes. [129]
Vaginal weight had a 1.46x increase after a two-week treatment of 10 mg/kg/day of ospemifene. [10] The number of progesterone receptors was increased in the vaginal stroma and epithelium, which indicates that ospemifene has "estrogenic activity." [10] Two 12-week phase 3 clinical trials were performed for ospemifene. [14]
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