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Pepsin / ˈ p ɛ p s ɪ n / is an endopeptidase that breaks down proteins into smaller peptides and amino acids. It is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin is an aspartic protease, using a catalytic aspartate in its active site. [2]
n/a Ensembl ENSG00000229859 n/a UniProt P0DJD8 n/a RefSeq (mRNA) NM_001079807 n/a RefSeq (protein) NP_001073275 n/a Location (UCSC) Chr 11: 61.2 – 61.21 Mb n/a PubMed search n/a Wikidata View/Edit Human Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. Function This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the ...
Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells. [2] This type of cell also secretes gastric lipase enzymes, which help digest triglycerides into free fatty acids and di- and mono-glycerides. [3] There is also evidence that the gastric chief cell ...
Gastrin is a hormone produced by enteroendocrine G cells in the pyloric glands. [1] All three of these stimulate parietal cells to secrete hydrochloric acid and intrinsic factor. The chief cells secrete pepsinogen in response to gastrin and especially Ach, and ACh also stimulates mucus secretion. [1]
Gastric chief cells are generally located deep in the mucosal layer of the stomach lining, in the fundus and body of the stomach. [2] [3] Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach.
Acinar cells: Mainly responsible for production of the inactive pancreatic enzymes that, once present in the small bowel, become activated and perform their major digestive functions by breaking down proteins, fat, and DNA/RNA. Acinar cells are stimulated by cholecystokinin (CCK), which is a hormone/neurotransmitter produced by the intestinal ...
The enzyme is first made in the inactive form, pepsinogen by chief cells in the lining of the stomach. [24] With an impulse from the vagus nerve, pepsinogen is secreted into the stomach, where it mixes with hydrochloric acid to form pepsin. [25] Once active, pepsin works to break down proteins in foods such as dairy, meat, and eggs. [24]
A peptide hormone, gastrin, produced by G cells in the gastric glands, stimulates the production of gastric juice which activates the digestive enzymes. Pepsinogen is a precursor enzyme produced by the gastric chief cells, and gastric acid activates this to the enzyme pepsin which begins the digestion of proteins. As these two chemicals would ...