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Although foods such as meat and seafood can elevate serum urate levels, genetic variation is a much greater contributor to high serum urate. [ 26 ] [ 27 ] A proportion of people have mutations in the urate transport proteins responsible for the excretion of uric acid by the kidneys.
Hyperuricaemia or hyperuricemia is an abnormally high level of uric acid in the blood.In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. [1] [2] Serum uric acid concentrations greater than 6 mg/dL for females, 7 mg/dL for males, and 5.5 mg/dL for youth (under 18 years old) are defined as hyperuricemia. [3]
This can occur because of diet, genetic predisposition, or underexcretion of urate, the salts of uric acid. [1] Underexcretion of uric acid by the kidney is the primary cause of hyperuricemia in about 90% of cases, while overproduction is the cause in less than 10%. [ 5 ]
Hypouricemia or hypouricaemia is a level of uric acid in blood serum that is below normal. In humans, the normal range of this blood component has a lower threshold set variously in the range of 2 mg/dL to 4 mg/dL, while the upper threshold is 530 μmol/L (6 mg/dL) for women and 619 μmol/L (7 mg/dL) for men. [1]
So, if for example you’re 65 and older and weigh 165 pounds (about 75 kilograms), you’ll want to eat a minimum of 60 grams of protein daily, according to the Mayo Clinic.
BMI vs. Body Fat Percentage. BMI and body fat percentage are both ways of determining whether a person has a healthy weight or not. A high BMI can indicate a high body fat percentage, but it’s ...
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A tophus (Latin: "stone", pl.: tophi) is a deposit of monosodium urate crystals, in people with longstanding high levels of uric acid (urate) in the blood, a condition known as hyperuricemia. Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of ...