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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
This can also be seen from the geometric picture: the trapezoids include all of the area under the curve and extend over it. Similarly, a concave-down function yields an underestimate because area is unaccounted for under the curve, but none is counted above. If the interval of the integral being approximated includes an inflection point, the ...
Integration, the process of computing an integral, is one of the two fundamental operations of calculus, [a] the other being differentiation. Integration was initially used to solve problems in mathematics and physics, such as finding the area under a curve, or determining displacement from velocity. Usage of integration expanded to a wide ...
In qualitative terms, a line integral in vector calculus can be thought of as a measure of the total effect of a given tensor field along a given curve. For example, the line integral over a scalar field (rank 0 tensor) can be interpreted as the area under the field carved out by a particular curve.
The term "quadrature" is a traditional term for area; the integral is geometrically interpreted as the area under the curve y = x n. Traditionally important cases are y = x 2 , the quadrature of the parabola , known in antiquity, and y = 1/ x , the quadrature of the hyperbola , whose value is a logarithm .
The Lebesgue integral describes better how and when it is possible to take limits under the integral sign (via the monotone convergence theorem and dominated convergence theorem). While the Riemann integral considers the area under a curve as made out of vertical rectangles, the Lebesgue definition considers horizontal slabs that are not ...
The integral as the area of a region under a curve. A sequence of Riemann sums over a regular partition of an interval. The number on top is the total area of the rectangles, which converges to the integral of the function. The partition does not need to be regular, as shown here.
Numerical integration has roots in the geometrical problem of finding a square with the same area as a given plane figure (quadrature or squaring), as in the quadrature of the circle. The term is also sometimes used to describe the numerical solution of differential equations .