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Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [2] [8] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Higher red blood cell diameter and wider variation in size are often seen in pernicious anaemia. [3] Lower diameter with normal variation in size are often seen after haemorrhage . [ 3 ] A higher variation in size is known as anisocytosis .
Nutritional anemia can be caused by a lack of iron, protein, vitamin B12, and other vitamins and minerals that are needed for the formation of hemoglobin. However, Iron deficiency anemia is the most common nutritional disorder. [7] Signs of anemia include cyanosis, jaundice, and easy bruising. [7]
Pernicious anemia: D51.0: 9870: Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B 12.
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A defect in either of these protein components can cause this syndrome. This is a rare disease, with a prevalence about 1 in 200,000, [1] and is usually seen in patients of European ancestry. Vitamin B 12 is an important vitamin needed for proper functioning of the bone marrow; if deficient, this may lead to decreased marrow output and anemia.
Megaloblastic anemia (MA) is associated with GSE and is believed to be the result of B 12 and folate deficiency. [23] In GSE, it appears to be associated with the IgA-less phenotype. [24] Unlike other forms of megaloblastic anemia, GSEA MA is not a form of autoimmune gastritis. [25] Pernicious anemia (PA).