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  2. Human mitochondrial molecular clock - Wikipedia

    en.wikipedia.org/wiki/Human_mitochondrial...

    Loogvali et al. (2009) only consider synonymous mutations, they have recalibrated the molecular clock of human mtDNA as 7990 years per synonymous mutation over the mitochondrial genome. [1] Soares et al. (2009) consider both coding and non-coding region mutations to arrive at a single mutation rate, but apply a correction factor to account for ...

  3. Mitochondrial Eve - Wikipedia

    en.wikipedia.org/wiki/Mitochondrial_Eve

    Early research using molecular clock methods was done during the late 1970s to early 1980s. Allan Wilson, Mark Stoneking, Rebecca L. Cann and Wesley Brown found that mutation in human mtDNA was unexpectedly fast, at 0.02 substitution per base (1%) in a million years, which is 5–10 times faster than in nuclear DNA. [8]

  4. Human mitochondrial genetics - Wikipedia

    en.wikipedia.org/wiki/Human_mitochondrial_genetics

    Mitochondrial diseases range in severity from asymptomatic to fatal, and are most commonly due to inherited rather than acquired mutations of mitochondrial DNA. A given mitochondrial mutation can cause various diseases depending on the severity of the problem in the mitochondria and the tissue the affected mitochondria are in.

  5. Molecular clock - Wikipedia

    en.wikipedia.org/wiki/Molecular_clock

    The molecular clock is a figurative term for a technique that uses the mutation rate of biomolecules to deduce the time in prehistory when two or more life forms diverged. The biomolecular data used for such calculations are usually nucleotide sequences for DNA , RNA , or amino acid sequences for proteins .

  6. Human mitochondrial DNA haplogroup - Wikipedia

    en.wikipedia.org/wiki/Human_mitochondrial_DNA_ha...

    The hypothetical woman at the root of all these groups (meaning just the mitochondrial DNA haplogroups) is the matrilineal most recent common ancestor (MRCA) for all currently living humans. She is commonly called Mitochondrial Eve. The rate at which mitochondrial DNA mutates is known as the mitochondrial molecular clock. It is an area of ...

  7. Apoptosome - Wikipedia

    en.wikipedia.org/wiki/Apoptosome

    Mutations of the cell pathway can either promote cell death or disallow cell death creating a huge amount of disease in the body. Mutated apoptosis pathways causing disease are plentiful and have a wide range from cancer, due to lack of apoptosome activity, Alzheimer's disease due to too much apoptosome activity, and many other ...

  8. Apoptosis - Wikipedia

    en.wikipedia.org/wiki/Apoptosis

    On the other hand, loss of control of cell death (resulting in excess apoptosis) can lead to neurodegenerative diseases, hematologic diseases, and tissue damage. Neurons that rely on mitochondrial respiration undergo apoptosis in neurodegenerative diseases such as Alzheimer's [99] and Parkinson's.

  9. Heteroplasmy - Wikipedia

    en.wikipedia.org/wiki/Heteroplasmy

    At birth, all copies of mitochondrial DNA are thought to be identical in most humans. [2] Microheteroplasmy is mutations of up to about 2−5% of mitochondrial genomes, and is present in most adults. This refers to hundreds of independent mutations in one organism, with each mutation found in about 1–2% of all mitochondrial genomes. [3]