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In most cases of fatal overdose it is likely that lack of opioid tolerance combined with the depressant effects of benzodiazepines is the cause of death. [ 23 ] The symptoms of an overdose such as sleepiness , agitation and ataxia occur much more frequently and severely in children.
Benzodiazepine overdose. Benzodiazepine dependence ( BZD dependence) defines a situation in which one has developed one or more of either tolerance, withdrawal symptoms, drug seeking behaviors, such as continued use despite harmful effects, and maladaptive pattern of substance use, according to the DSM-IV.
After withdrawal, no patients took any further overdoses after one year post-withdrawal. The cause of the deteriorating mental and physical health in a significant proportion of patients was hypothesised to be caused by increasing tolerance where withdrawal-type symptoms emerged, despite the administration of stable prescribed doses. [53]
Barbiturate overdose may occur by accident or purposefully in an attempt to cause death. [3] The toxic effects are additive to those of alcohol and benzodiazepines. [3] The lethal dose varies with a person's tolerance and how the drug is taken. [3] The effects of barbiturates occur via the GABA neurotransmitter. [2]
Myth: Fentanyl is so powerful that touching it or being close to it can cause overdose. ... because people may not have the necessary tolerance to handle the substance.
v. t. e. Benzodiazepine use disorder ( BUD ), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. [2] [3] Benzodiazepines are one of the more common prescription drugs used recreationally.
An overdose can cause stupor, changes in pupil size, clammy skin, cyanosis, coma and respiratory failure leading to death. ... tolerance and past usage,” according to the DEA. ...
t. e. Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects. Drug tolerance is indicative of drug use but is not necessarily ...