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A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. [1] Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue.
The dawn of contemporary psychopharmacology marked the beginning of the use of psychiatric drugs to treat psychological illnesses. It brought with it the use of opiates and barbiturates for the management of acute behavioral issues in patients.
Pain tolerance is the maximum level of pain that a person is able to tolerate. Pain tolerance is distinct from pain threshold (the point at which pain begins to be felt). [1] The perception of pain that goes in to pain tolerance has two major components. First is the biological component—the headache or skin prickling that activates pain ...
Incentive salience is a cognitive process that grants a "desire" or "want" attribute, which includes a motivational component to a rewarding stimulus. [1] [2] [3] [9] Reward is the attractive and motivational property of a stimulus that induces appetitive behavior – also known as approach behavior – and consummatory behavior. [3]
The meaning of spirituality has developed and expanded over time, and various meanings can be found alongside each other. [1] [2] [3] [note 1] Traditionally, spirituality referred to a religious process of re-formation which "aims to recover the original shape of man", [note 2] oriented at "the image of God" [4] [5] as exemplified by the founders and sacred texts of the religions of the world.
Physiological agonism describes the action of a substance which ultimately produces the same effects in the body as another substance—as if they were both agonists at the same receptor—without actually binding to the same receptor.
In drug dependent individuals, negative reinforcement occurs when a drug is self-administered in order to alleviate or "escape" the symptoms of physical dependence (e.g., tremors and sweating) and/or psychological dependence (e.g., anhedonia, restlessness, irritability, and anxiety) that arise during the state of drug withdrawal.
In pharmacology, efficacy (E max) is the maximum response achievable from an applied or dosed agent, for instance, a small molecule drug. [2] Intrinsic activity is a relative term for a drug's efficacy relative to a drug with the highest observed efficacy. [3] It is a purely descriptive term that has little or no mechanistic interpretation.