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Bipolar disorder is a mood disorder characterized by alternating periods of manic (elevated) and depressed mood.While the exact cause and mechanism of bipolar disorder remain unknown, ongoing research focuses on uncovering its biological origins.
The causes of bipolar disorder likely vary between individuals and the exact mechanism underlying the disorder remains unclear. [53] Genetic influences are believed to account for 73–93% of the risk of developing the disorder indicating a strong hereditary component. [13] The overall heritability of the bipolar spectrum has been estimated at ...
Bipolar disorder has one of the highest rates of suicide amongst psychiatric disorders, as well as high comorbidity rates with alcohol and substance use disorders. [2] Bipolar disorder has a genetic component. [3] This means that the sequence of nucleotides in DNA contains information that can lead to bipolar disorder in individuals ...
Older twin studies suggest that 79 percent to 93 percent of the risk of bipolar disorder is genetic. ... While environmental factors aren’t thought to cause bipolar disorder, they may trigger an ...
A systematic comparative analysis of shared and unique genetic factors highlighted key gene sets and molecular processes underlying six major neuropsychiatric disorders: attention deficit hyperactivity disorder, anxiety disorders, autistic spectrum disorders, bipolar disorder, major depressive disorder, and schizophrenia. [9]
Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. [7] [8] Correlations between mental disorders and substance use are also found to have a two way relationship, in that substance use can lead to the development of mental disorders and having mental disorders can lead to substance use/abuse.
Mania is a syndrome with multiple causes. [7] Although the vast majority of cases occur in the context of bipolar disorder, it is a key component of other psychiatric disorders (such as schizoaffective disorder, bipolar type) and may also occur secondary to various general medical conditions, such as multiple sclerosis; certain medications may perpetuate a manic state, for example prednisone ...
Electroconvulsive therapy has also proved to be a successful short-term treatment for depressive symptoms of bipolar disorder and related illnesses, although the reasons for its success are almost completely unknown. There is also evidence for a genetic factor in causing psychological illness.
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