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Ketotifen is an antihistamine medication and a mast cell stabilizer used to treat allergic conditions such as conjunctivitis, asthma, and urticaria (hives).Ketotifen is available in ophthalmic (eye drops or drug-eluting contact lenses) and oral (tablets or syrup) forms: the ophthalmic form relieves eye itchiness and irritation associated with seasonal allergies, while the oral form helps ...
Norketotifen is a pharmaceutical medication which is not yet approved for use and is undergoing clinical trials. It is a biologically active demethylated metabolite of ketotifen and has a similar potency as ketotifen as an antihistamine H 1 medication and a mast cell stabilizer, yet is devoid of severe sedative effects of ketotifen, potentially allowing for higher doses to be administered ...
10-Hydroxyketotifen (WR621365) [1] is a biologically inactive metabolite of ketotifen. [2] [3] [4] Despite the mainstream scientific consensus that 10-hydroxyketotifen is a biologically inactive compound, its pharmacological properties are not very well studied outside the context of ketotifen, therefore, 10-hydroxyketotifen may still possess biological activity similarly to norketotifen ...
Corticosteroids are another option, but, considering the side-effects of cataracts and increased intraocular pressure, corticosteroids are reserved for more severe forms of allergic conjunctivitis such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). [2]
Decreasing oxygenation to the eye can result in undesirable side effects. [5] Researchers in this field have noted that different types of contact lenses have varying degrees of oxygen permeability. For example, it has been shown that SCLs have limited oxygen permeability while silicon-based contact lenses have much better oxygen permeability.
Artificial tear eye-drops or ointments may be a suitable treatment for mild cases. Low-dosage steroidal eye-drops, such as prednisone, fluorometholone, loteprednol (Lotemax 0.5%) or rimexolone. Steroidal drops should be used with caution [5] and the eye pressure should be regularly checked during treatment. Soft contact lenses.
Lifitegrast, sold under the brand name Xiidra (/ ˈ z aɪ d r ə / [2]), is a medication for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis sicca.
After cataract surgery, patients with diabetes mellitus are generally acknowledged to have an increased risk of macular edema. [ 12 ] A prior history of retinal vein occlusion was the only significant preoperative risk factor in a large retrospective series of 1659 consecutive cataract surgeries.