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  2. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    By NMR-guided simulations, amyloid beta 1-40 and amyloid beta 1-42 also seem to feature highly different conformational states, [59] with the C-terminus of amyloid beta 1-42 being more structured than that of the 1-40 fragment. Low-temperature and low-salt conditions allowed to isolate pentameric disc-shaped oligomers devoid of beta structure. [60]

  3. P3 peptide - Wikipedia

    en.wikipedia.org/wiki/P3_peptide

    p3 peptide generates from the 17-40 or 17-42 sequence of the amyloid precursor protein , which is a type I integral membrane protein concerned in neurons’ synapses in many human tissues. Under normal physiological conditions, APP is processed with three different proteolytic enzymes: α-, β-and γ-secretases. At first, APP molecule is cut by ...

  4. Biomarkers of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_Alzheimer's...

    Amyloid beta (Aβ) is composed of a family of peptides produced by proteolytic cleavage of the type I transmembrane spanning glycoprotein amyloid-beta precursor protein (APP). Amyloid plaque Aβ protein species ends in residue 40 or 42, [ 4 ] but it is suspected that Aβ42 form is crucial in the pathogenesis of AD.

  5. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, that is released from a longer parent protein called the Aβ-precursor protein (APP). [24] APP is produced by many types of cell in the body, but it is especially abundant in neurons. It is a single-pass transmembrane protein, passing once through cellular ...

  6. Gamma secretase - Wikipedia

    en.wikipedia.org/wiki/Gamma_secretase

    The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that, when cleaved by both gamma and beta secretase, produces a short 37-43 [verification needed] amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the ...

  7. Amyloid-beta precursor protein - Wikipedia

    en.wikipedia.org/wiki/Amyloid-beta_precursor_protein

    Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [ 5 ] and has been implicated as a regulator of synapse formation , [ 6 ] neural plasticity , [ 7 ] antimicrobial activity, [ 8 ] and iron export . [ 9 ]

  8. Losing Weight After 50 Is Possible: 21 Effective Tips From ...

    www.aol.com/losing-weight-50-possible-21...

    December 26, 2024 at 4:42 PM "Hearst Magazines and Yahoo may earn commission or revenue on some items through these links." While losing weight after 50 may present some unique challenges, it can ...

  9. Beta-secretase 1 - Wikipedia

    en.wikipedia.org/wiki/Beta-secretase_1

    Processing of the amyloid precursor protein. BACE1 is the major beta secretase for the generation of amyloid-β peptides in the neurons. [9]Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the amyloid precursor protein (APP).