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GSE, particularly coeliac disease, increases the risk of cancers of specific types. [114] There are two predominant cancers associated with coeliac disease, cancer of the esophagus and lymphoproliferative diseases such as gluten-sensitive enteropathy-associated T-cell lymphoma (EATL). [115]
Conditions that may present similarly include celiac disease, bile acid malabsorption, colon cancer, and dyssynergic defecation. [7] Ruling out parasitic infections, lactose intolerance, small intestinal bacterial overgrowth, and celiac disease is recommended before a diagnosis of IBS is made. [68]
Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye, spelt and barley. [10]
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Autoimmune disease Primary organ/body part affected Autoantibodies Acceptance as an autoimmune disease Prevalence rate (US) Cit. Autoimmune enteropathy: Small intestine: Anti-enterocyte antibodies Probable Rare [24] Autoimmune hepatitis: Liver: ANA, ASMA, anti-LKM1 Confirmed 1 in 10,000 to 1 in 50,000 [25] Celiac disease: Small intestine
Based on histologic findings the differential diagnosis of pediatric autoimmune enteropathy is graft-versus-host disease, Crohn's disease, and food sensitivity enteropathies such as celiac disease and lactose intolerance. [6] Lactose intolerance should be excluded in infants with intractable diarrhea.
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A well studied model is celiac disease, in which increased intestinal permeability appears secondary to the abnormal immune reaction induced by gluten and allows fragments of gliadin protein to get past the intestinal epithelium, triggering an immune response at the intestinal submucosa level that leads to diverse gastrointestinal or extra ...