Search results
Results from the WOW.Com Content Network
The entorhinal cortex is the first area of the brain to be affected in Alzheimer's disease; in year 2013, a functional magnetic resonance imaging study has localised the area to the lateral entorhinal cortex. [15]
A recent hypothesis postulates that CA3 sequences are built up pair by pair during memory encoding, relying on precisely timed, phase-precessing input from the entorhinal cortex. [10] This mechanism is based on the synapses of the CA3 recurrent axon corraterals on the dendrites of the CA3 population [11] that form a complete matrix of connections.
The entorhinal cortex (EC) is a major part of the hippocampal formation of the brain, and is reciprocally connected with the hippocampus. [1]The hippocampal formation, which consists of the hippocampus, perirhinal cortex, the dentate gyrus, the subicular areas and the EC forms one of the most important parts of the limbic system.
HD cells are found in many brain areas, including the cortical regions of postsubiculum (also known as the dorsal presubiculum), retrosplenial cortex, [10] and entorhinal cortex, [11] and subcortical regions including the thalamus (the anterior dorsal [12] and the lateral dorsal [13] thalamic nuclei), lateral mammillary nucleus, [14] dorsal ...
The anterior part of the gyrus includes the perirhinal and entorhinal cortices [citation needed]. The term parahippocampal cortex is used to refer to an area that encompasses both the posterior parahippocampal gyrus and the medial portion of the fusiform gyrus [ citation needed ] .
However, later work did confirm that the olfactory bulb does project into the ventral part of the lateral entorhinal cortex, and field CA1 in the ventral hippocampus sends axons to the main olfactory bulb, [45] the anterior olfactory nucleus, and to the primary olfactory cortex. There continues to be some interest in hippocampal olfactory ...
This is why after a stroke people have a chance of developing cognitive deficits that result in anterograde amnesia, since strokes can involve the temporal lobe in the temporal cortex, and the temporal cortex houses the hippocampus. Anterograde amnesia can be the first clinical sign that Alzheimer's disease is developing within the brain ...
Rat studies indicate that lesioning of the subiculum decreases the spread of amyloid-beta in rat models of Alzheimer's disease. Alzheimer's disease pathology is thought to have prion-like properties. The disease tends to spread in characteristic sequence from the entorhinal cortex through the subiculum. [12]