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An antibody molecule. The two heavy chains are colored red, blue, and purple. The two light chains green and yellow. See also: The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains.
Schematic diagram of a typical antibody showing two Ig heavy chains (purple) joined by disulfide bonds to two Ig light chains (green). The constant (C) and variable (V) domains are shown. An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. [1]
Antibodies are heavy (~150 kDa) proteins of about 10 nm in size, [17] arranged in three globular regions that roughly form a Y shape.. In humans and most other mammals, an antibody unit consists of four polypeptide chains; two identical heavy chains and two identical light chains connected by disulfide bonds. [18]
Antibody (or immunoglobulin) structure is made up of two heavy-chains and two light-chains.These chains are held together by disulfide bonds.The arrangement or processes that put together different parts of this antibody molecule play important role in antibody diversity and production of different subclasses or classes of antibodies.
A heavy-chain antibody is an antibody which consists only of two heavy chains and lacks the two light chains usually found in antibodies. In common antibodies, the antigen binding region consists of the variable domains of the heavy and light chains (V H and V L). Heavy-chain antibodies can bind antigens despite having only V H domains.
The "upper" part of an antibody. The complementarity-determining regions of the heavy chain are shown in red (Complementarity-determining regions (CDRs) are polypeptide segments of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively. CDRs are where these molecules bind to their ...
Each heavy chain or light chain gene contains multiple copies of three different types of gene segments for the variable regions of the antibody proteins. For example, the human immunoglobulin heavy chain region contains 2 Constant (Cμ and Cδ) gene segments and 44 Variable (V) gene segments, plus 27 Diversity (D) gene segments and 6 Joining ...
Anti-Lambda Light Chain Type Description; Anti-Lambda Light Chain [N10/2] This is a recombinant monoclonal antibody to the Lambda light chain. It does not cross react with Kappa light chains. N10/2 most importantly recognizes pathologies such as leukemias, plasmacytomas, and non-Hodgkin's lymphomas. [22]