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2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
Dinitrophenols are chemical compounds which are nitro derivatives of phenol.. There are six isomers of dinitrophenol: Chemical structure of 2,4-Dinitrophenol. 2,3-Dinitrophenol; 2,4-Dinitrophenol
The substance has killed at least 33 people in the UK
2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .
The substance has killed at least 33 people in the UK. For premium support please call: 800-290-4726 more ways to reach us
HU6 is a prodrug of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) that is intended to "minimize the rapid absorption and high peak blood concentrations of DNP to provide a wider therapeutic index and improve safety."
Overdose caused fatal hyperthermia and DNP also caused cataracts in some users. After the passage of the Food, Drug, and Cosmetic Act in 1938, the FDA banned DNP for human consumption. [37] Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by suppressing appetite, and had other ...
DNP may refer to: Science and technology. 2,4-Dinitrophenol, a small organic molecule formerly marketed as a pharmaceutical "diet aid" Deoxyribonucleoprotein, a ...