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Paget's disease of the breast can affect the nipple and areola: the nipple is typically affected first and then the skin changes spread to the areola. It is common for symptoms to wax and wane. Symptoms typically only affect one breast and may include: Skin: The first symptom is usually an eczema-like rash.
The term breast eczema refers to benign dermatitis seen in the skin of the breast. It can affect the nipples, areolae, and surrounding areas. Eczema of the nipples is the moist type, with oozing and crusting. Painful fissuring is frequently seen, especially in nursing mothers. [1]: 78 It will often occur in pregnancy, even without breastfeeding.
The cause of the disease is a haploinsufficiency of the enzyme ATP2C1; [7] the ATP2C1 gene is located on chromosome 3, which encodes the protein hSPCA1.A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes.
Other symptoms to note: Chicken pox rashes typically start toward the middle of the body and work outward toward the extremities. It can often cause pockmarked scars after the blisters heal.
Extramammary Paget's disease (EMPD) is a rare and slow-growing cancer, which occurs within the epithelial tissues [1] and accounts for 6.5% of all Paget's disease. [2] This disease presents similarly to the more conventional form of mammary Paget's disease (MPD). [3]
Intertrigo, commonly called “skin fold dermatitis”, refers to a type of inflammatory rash of the superficial skin that occurs within a person's body folds. [1] These areas are more susceptible to irritation and subsequent infection due to factors that promote skin breakdown such as moisture, friction, and exposure to bodily secretions and excreta such as sweat, urine, or feces. [1]
Most of the women first experience the flu-like symptoms and just after they may notice a sore red area on the breast. Also, women should seek medical care if they notice any abnormal discharge from the nipples , if breast pain is making it difficult to function each day, or they have prolonged, unexplained breast pain.
Breast pain is the symptom of discomfort in either one or both breasts. [2] Pain in both breasts is often described as breast tenderness, is usually associated with the menstrual period and is not serious. [1] [3] Pain that involves only one part of a breast is more concerning, [1] particularly if a hard mass or nipple discharge is also present ...
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