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The vestibular system's semicircular canal – a cross-section. This is the site of cinnarizine's anti-vertigo action. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus by limiting the activity of the vestibular hair cells which send signals about ...
"Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study". Clin Ther . 26 (6): 866– 77.
Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. [2] It may also be used for nausea after general anaesthesia or that which developed from opioid use. [2] [3] It is taken by mouth, in the rectum, or injected into a vein. [3] [4]
The main symptoms are severe vertigo and nystagmus. The most common symptom of vestibular neuritis is the onset of vertigo that has formed from an ongoing infection or trauma. [9] The dizziness sensation that is associated with vertigo is thought to be from the inner ear labyrinth. [10]
Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D 2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels.
Hydroamination has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both vertigo and motion sickness related nausea. [26] Synthesis of cinnarizine via hydroamination. Hydroamination is also promising for the synthesis of alkaloids. An example was the hydroamination step used in the total synthesis ...
Meclizine is effective in inhibiting nausea, vomiting, and dizziness caused by motion sickness. [10] The drug is safe for treating nausea in pregnancy and is a first-line therapy for this use. [11] [12] Meclizine may not be strong enough for especially sickening motion stimuli, and second-line defenses should be tried in those cases. [13]
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8]
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