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  2. KRAS - Wikipedia

    en.wikipedia.org/wiki/KRAS

    The impact of KRAS mutations is heavily dependent on the order of mutations. Primary KRAS mutations generally lead to a self-limiting hyperplastic or borderline lesion, but if they occur after a previous APC mutation it often progresses to cancer. [18] KRAS mutations are more commonly observed in cecal cancers than colorectal cancers located in ...

  3. Intraductal papillary mucinous neoplasm - Wikipedia

    en.wikipedia.org/wiki/Intraductal_papillary...

    Histopathology of IPMN types in a distal pancreatectomy specimen from a 60-year-old man, by gross pathology (center image), microscopy and immunohistochemistry: The resected specimen (c) revealed that the mural nodule in the MPD consisted of PB-type IPMN with high-grade dysplasia (adenocarcinoma) (a) with a diffuse positivity of p53 immunostaining (an insert) and KRAS mutation (G12V).

  4. mRNA-5671 - Wikipedia

    en.wikipedia.org/wiki/MRNA-5671

    It is a tetravalent vaccine that targets G12D, G12V, G13D or G12C driver mutations in the KRAS gene. [2] It is currently being evaluated for the treatment of either non-small cell lung cancer, colorectal cancers with microsatellite instability, or pancreatic adenocarcinoma, all with confirmed KRAS driver mutations. [3]

  5. K-Ras(G12C) inhibitor 6 - Wikipedia

    en.wikipedia.org/wiki/K-Ras(G12C)_inhibitor_6

    K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP.Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a "pocket", or binding site, of mutant K-Ras.

  6. Cetuximab - Wikipedia

    en.wikipedia.org/wiki/Cetuximab

    Accordingly, genetic testing to confirm the absence of KRAS mutations (and so the presence of the KRAS wild-type gene), is now clinically routine before the start of treatment with EGFR inhibitors. mCRC patients with wild-type KRAS tumors have been shown to benefit from a response rate of over 60% and a decreased risk for progression of over 40 ...

  7. Ras GTPase - Wikipedia

    en.wikipedia.org/wiki/Ras_GTPase

    The most common mutations are found at residue G12 in the P-loop and the catalytic residue Q61. The glycine to valine mutation at residue 12 renders the GTPase domain of Ras insensitive to inactivation by GAP and thus stuck in the "on state". Ras requires a GAP for inactivation as it is a relatively poor catalyst on its own, as opposed to other ...

  8. Some winter viruses could trigger heart complications ... - AOL

    www.aol.com/winter-viruses-could-trigger-heart...

    Johanna Contreras, M.D., a cardiologist at Mount Sinai Fuster Heart Hospital in New York City, said she has seen people mistaking virus symptoms for serious heart complications.. Some patients who ...

  9. Familial adenomatous polyposis - Wikipedia

    en.wikipedia.org/wiki/Familial_adenomatous_polyposis

    APC mutations have been linked to certain other cancers such as thyroid cancer. As the mutation causing FAP is autosomal dominant, it can be inherited directly from either parent to a child. A genetic blood test of the APC gene exists that can determine whether it is present, and therefore can predict the possibility of FAP. Individuals at risk ...