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Haemophilia (British English), or hemophilia (American English) [6] (from Ancient Greek αἷμα (haîma) 'blood' and φιλία (philía) 'love of'), [7] is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding.
The avoidance of expression of such deleterious recessive alleles caused by inbreeding, via inbreeding avoidance mechanisms, is the main selective reason for outcrossing. [ 6 ] [ 7 ] Crossbreeding between populations sometimes has positive effects on fitness-related traits, [ 8 ] but also sometimes leads to negative effects known as outbreeding ...
"Hemophilia: The Royal Disease" Yelena Aronova-Tiuntseva and Clyde Freeman Herreid; Family tree of Queen Victoria and her descendants; Haemophilia in Queen Victoria's Descendants. Archived 2006-11-18 at the Wayback Machine; Victor A. McKusick (August 1965). "The Royal Hemophilia". Scientific American. pp. 88– 95
Genetic purging is the increased pressure of natural selection against deleterious alleles prompted by inbreeding. [1]Purging occurs because deleterious alleles tend to be recessive, which means that they only express all their harmful effects when they are present in the two copies of the individual (i.e., in homozygosis).
X chromosome. The factor IX gene is located on the X chromosome (Xq27.1-q27.2). It is an X-linked recessive trait, which explains why males are affected in greater numbers. [9] [10] A change in the F9 gene, which makes blood clotting factor IX (9), causes haemophilia B. [11]
About 4,000 years ago, the last of Earth's woolly mammoths died out on a lonely Arctic Ocean island off the coast of Siberia, a melancholy end to one of the world's charismatic Ice Age animals.
Tay–Sachs disease, which can present as a fatal illness of children that causes mental deterioration prior to death, was historically extremely common among Ashkenazi Jews, [19] with lower levels of the disease in some Pennsylvania Dutch, Italian, Irish Catholic, and French Canadian descent, especially those living in the Cajun community of ...
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child.
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