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  2. Neurofibrillary tangle - Wikipedia

    en.wikipedia.org/wiki/Neurofibrillary_tangle

    Microscopy of a cell with neurofibrillary tangles (marked by arrows) Neurofibrillary tangles (NFTs) are intracellular aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their ...

  3. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...

  4. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    Fundamental to the understanding of Alzheimer's disease is the biochemical events that leads to accumulation of the amyloid-beta plaques and tau-protein tangles. A delicate balance of the enzymes secretases regulate the amyloid-beta accumulation.

  5. Study detects early Alzheimer's 'stealth' phase before ... - AOL

    www.aol.com/study-detects-early-alzheimers...

    The second phase, which coincides with the development of symptoms, is more destructive and is characterized by the accumulation of plaques, tangles, and other Alzheimer’s hallmarks. The ...

  6. Study challenges current views about toxic plaque formation ...

    www.aol.com/study-challenges-current-views-toxic...

    New research is contradicting previously held views that only neurons secret beta-amyloid that forms toxic plaques, a marker of Alzheimer's disease in the brain. The study points to another ...

  7. Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Alzheimer's_disease

    Alzheimer's disease has been identified as a protein misfolding disease, a proteopathy, caused by the accumulation of abnormally folded amyloid beta protein into amyloid plaques, and tau protein into neurofibrillary tangles in the brain. [77]

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