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Triphenyl phosphate exhibits low acute toxicity by dermal or oral contact. [3] However, an increasing number of studies have linked exposure to TPhP with reproductive and developmental toxicity, neurotoxicity, metabolic disruption, endocrine effects, and genotoxicity. [6] [8] [9] TPhP has also been found to induce significant estrogenic activity.
Neurotoxic effects have also been linked to poisoning with OP pesticides causing four neurotoxic effects in humans: cholinergic syndrome, intermediate syndrome, organophosphate-induced delayed polyneuropathy (OPIDP), and chronic organophosphate-induced neuropsychiatric disorder (COPIND). These syndromes result after acute and chronic exposure ...
The most dangerous isomers are considered to be those containing ortho isomers, such as tri-ortho-cresyl phosphate, TOCP.The World Health Organization stated in 1990 that "Because of considerable variation among individuals in sensitivity to TOCP, it is not possible to establish a safe level of exposure" and "TOCP are therefore considered major hazards to human health."
The phosphorus-containing product is triphenylphosphine sulfide, Ph 3 PS. This reaction can be employed to assay the "labile" S 0 content of a sample, say vulcanized rubber. Triphenylphosphine selenide, Ph 3 PSe, may be easily prepared via treatment of PPh 3 with red (alpha-monoclinic) Se. Salts of selenocyanate, SeCN −, are used as the Se 0 ...
Pyridoxine is converted to pyridoxal phosphate via two enzymes, pyridoxal kinase and pyridoxine 5′-phosphate oxidase. High levels of pyridoxine can inhibit these enzymes. As pyridoxal phosphate is the active form of vitamin B 6, this saturation of pyridoxine could mimic a deficiency of vitamin B 6. [23] [27]
Triphenylphosphine oxide (often abbreviated TPPO) is the organophosphorus compound with the formula OP(C 6 H 5) 3, also written as Ph 3 PO or PPh 3 O (Ph = C 6 H 5).It is one of the more common phosphine oxides.
Tris(1,3-dichloroisopropyl)phosphate (TDCPP) is a chlorinated organophosphate. Organophosphate chemicals have a wide variety of applications and are used as flame retardants , pesticides , plasticizers , and nerve gases .
Specific treatments for acute pesticide poisoning are often dependent on the pesticide or class of pesticide responsible for the poisoning. However, there are basic management techniques that are applicable to most acute poisonings, including skin decontamination, airway protection, gastrointestinal decontamination, and seizure treatment.