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Anne-Claude Gingras FRSC is a senior investigator at Lunenfeld-Tanenbaum Research Institute, and a professor in the department of molecular genetics at the University of Toronto. [1] She is an expert in mass spectrometry based proteomics technology that allows identification and quantification of protein from various biological samples.
Van Eyk is a member-at-large and a council member of Human Proteome Organization, [6] and the president of US Human Proteome Organization. [7] She was a technical briefs editor at Proteomics. [8] She served on the editorial board of Proteomics: clinical application and Journal of Physiology and Circulation Research. [9]
Robotic preparation of MALDI mass spectrometry samples on a sample carrier. Proteomics is the large-scale study of proteins. [1] [2] Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA.
Proteomic profiling is the large-scale analysis of proteins, which is essential for understanding biological processes and disease mechanisms.A proteomic profile may be employed to discover or diagnose diseases or conditions, which can monitor responses to therapeutic measures.
The Human Proteome Organization has served as a coordinating body for many long-running proteomics research projects associated with specific human tissues of clinical interest, such as blood plasma, [3] liver, [4] brain [5] and urine. [6]
Historically, thermal proteome profiling has been assessed using a western blot against a known target of interest. With the advent of high resolution Orbitrap mass spectrometers , this type of experiment can be executed on a proteome -wide scale and stability curves can be generated for thousands of proteins at once.
Research in the Rhoades lab aims to elucidate the principles that link protein conformational change with structure-function relationships, focusing on understanding structural plasticity in intrinsically disordered proteins. These proteins do not form stable structures under physiological conditions; for many, function is dependent upon disorder.
Emma Lundberg is a Swedish cell biologist who is a professor at KTH Royal Institute of Technology and Director of Cell Profiling at the Science for Life Laboratory.Her research considers spatial proteomics and cell biology, making use of an antibody-based approach to assess fundamental aspects of human biology.