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Atezolizumab, sold under the brand name Tecentriq among others, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma and alveolar soft part sarcoma, [9] [11] but discontinued for use in triple-negative breast cancer (TNBC). [12]
The subcutaneous injection of atezolizumab and hyaluronidase was evaluated in IMscin001 (NCT03735121), an open-label, multi-center, international, randomized trial in adults with locally advanced or metastatic non-small cell lung cancer who were not previously exposed to cancer immunotherapy and who had disease progression following treatment with platinum-based chemotherapy. [2]
The study enrolled 34 patients, 28 of which underwent surgery to resect the PDAC. 19 of the patients who had undergone surgery then received atezolizumab, an immune checkpoint inhibitor. 16 of the patients on atezolizumab then received autogene cevumeran. 1 patient was considered to have insufficiently many neoantigens to manufacture the vaccine.
Atezolizumab (Tecentriq) is a fully humanised IgG1 (immunoglobulin 1) antibody developed by Roche Genentech. In 2016, the FDA approved atezolizumab for urothelial carcinoma and non-small cell lung cancer. Avelumab (Bavencio) is a fully human IgG1 antibody developed by Merck Serono and Pfizer.
Daei Sorkhabi A, ZareDini M, Fazlollahi A, Sarkesh A, Naseri A, Mousavi SE, et al. (December 2023). "The safety and efficacy of tislelizumab, alone or in combination with chemotherapy, for the treatment of non-small cell lung cancer: a systematic review of clinical trials". BMC Pulmonary Medicine. 23 (1): 495. doi: 10.1186/s12890-023-02755-3.
The Academy of Sciences of Albania (Albanian: Akademia e Shkencave e Shqipërisë), founded in 1972, is the most important scientific institution in Albania. [1] In the 1980s, several research institutes began at the University of Tirana were transferred to the Academy's jurisdiction. [2]
Etrolizumab (rhuMAb Beta7) is a biopharmaceutical drug candidate being developed for the treatment of ulcerative colitis and Crohn's disease.It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. [1]
The Albanians (Albanian: Shqiptarët) and their country Albania (Shqipëria) have been identified by many ethnonyms.The native endonym is Shqiptar.The name "Albanians" (Latin: Albanenses/Arbanenses) was used in medieval Greek and Latin documents that gradually entered European languages from which other similar derivative names emerged. [1]