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[3] [4] Generally, the use of a cerumenolytic involves instilling several drops of the product into the affected ear once or twice daily for a treatment duration of 3 to 5 days. [ 1 ] [ 4 ] Each instillation is relatively quick (less than 5 minutes) and can be done either at home or in a clinical setting.
The poor water solubility of dantrolene leads to certain difficulties in its use. [11] [16] A more water-soluble analog of dantrolene, azumolene, is under development for similar indications. [16] Azumolene has a bromine residue instead of the nitro group found in dantrolene, and is 30 times more water-soluble. [11]
After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. [5] Dantrolene remains the only drug known to be effective in the treatment of MH. [30] The recommended dose of dantrolene is 2.5 mg/kg, repeated as necessary. [5]
Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes
SHMP is used as a sequestrant and has applications within a wide variety of industries, including as a food additive in which it is used under the E number E452i. Sodium carbonate is sometimes added to SHMP to raise the pH to 8.0–8.6, which produces a number of SHMP products used for water softening and detergents.
Critics have long argued that while studying the effects of Red Dye No. 3 in humans poses ethical and scientific challenges, its ban in cosmetics should have logically extended to the food supply ...
Azumolene is an experimental drug which is a derivative of dantrolene. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of malignant hyperthermia but with better water solubility and lower toxicity, albeit with lower potency. [1] [2] [3]
As magnets affect water to a small degree, and water containing ions is more conductive than purer water, magnetic water treatment is an example of a valid scientific hypothesis that failed experimental testing and is thus disproven. Any products claiming to utilize magnetic water treatment are absolutely fraudulent. [1]
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