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Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]
While rare, lactic acidosis (when lactic acid, the same thing that makes you sore after a workout, builds up in the blood) can be a side effect in those with poor kidney or liver function or due ...
The drug metformin can cause lactic acidosis in patients with kidney failure because metformin inhibits the hepatic gluconeogenesis of the Cori cycle, particularly the mitochondrial respiratory chain complex 1. [8] The buildup of lactate and its substrates for lactate production, pyruvate and alanine, lead to excess lactate. [9]
Metformin is more commonly associated with gastrointestinal adverse effects than most other antidiabetic medications. [46] [76] The most serious potential adverse effect of metformin is lactic acidosis; this complication is rare, and seems to be related to impaired liver or kidney function.
Symptoms of lactic acidosis include nausea, vomiting, and weakness. ... Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can ...
Lactic acidosis (a buildup of lactic acid in your blood) is a potential serious side effect of metformin. Signs of this condition include feeling dizzy, having unusual muscle pain or a slow or ...
The most common causes of high anion gap metabolic acidosis are: ketoacidosis, lactic acidosis, kidney failure, and toxic ingestions. [3] Ketoacidosis can occur as a complication of diabetes mellitus (diabetic ketoacidosis), but can occur due to other disorders, such as chronic alcoholism and malnutrition. In these conditions, excessive free ...
The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [35] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [35]