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Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]
The drug metformin can cause lactic acidosis in patients with kidney failure because metformin inhibits the hepatic gluconeogenesis of the Cori cycle, particularly the mitochondrial respiratory chain complex 1. [8] The buildup of lactate and its substrates for lactate production, pyruvate and alanine, lead to excess lactate. [9]
Because metformin decreases liver uptake of lactate, any condition that may precipitate lactic acidosis is a contraindication. Common causes include alcoholism (due to depletion of NAD+ stores), heart failure, and respiratory disease (due to inadequate tissue oxygenation); the most common cause is kidney disease. [94]
While rare, lactic acidosis (when lactic acid, the same thing that makes you sore after a workout, builds up in the blood) can be a side effect in those with poor kidney or liver function or due ...
Lactic acidosis (a buildup of lactic acid in your blood) is a potential serious side effect of metformin. Signs of this condition include feeling dizzy, having unusual muscle pain or a slow or ...
Metformin is the simplest non-insulin diabetes medication approved for use during pregnancy because it cannot cause hypoglycemia. Still, research on the long-term effects on children born to women ...
fetal metabolic acidosis; elevated fetal blood lactate levels (from fetal scalp blood testing) indicating the baby has a lactic acidosis; Some of these signs are more reliable predictors of fetal compromise than others. For example, cardiotocography can give high false positive rates, even when interpreted by highly experienced medical ...
Symptoms of lactic acidosis include nausea, vomiting, and weakness. ... Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can ...
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