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Malathion is an acetylcholinesterase inhibitor, a diverse family of chemicals.Upon uptake into the target organism, it binds irreversibly to the serine residue in the active catalytic site of the cholinesterase enzyme.
Early symptoms include headache, dizziness, fast heart rate, shortness of breath, and vomiting. [2] This phase may then be followed by seizures, slow heart rate, low blood pressure, loss of consciousness, and cardiac arrest. [2] Onset of symptoms usually occurs within a few minutes. [2] [3] Some survivors have long-term neurological problems. [2]
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...
A few additional screening questions about the patient's work and home environment, in addition to a typical health questionnaire, can indicate whether there was a potential pesticide poisoning. [24] If one is regularly using carbamate and organophosphate pesticides, it is important to obtain a baseline cholinesterase test.
Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins).Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD). [1]
Symptoms typically include neurologic and gastrointestinal issues including: [4] [6] nausea; vomiting; diarrhea; numbness and tingling in the lips, mouth, face, and extremities; The latter has been described as "nerves being on fire" or "ants crawling and biting all over". [4] Other less common symptoms can include: [4] ataxia; loss of ...
Humans can be infected with many types of pathogens, including prions, viruses, bacteria, and fungi, causing symptoms like sneezing, coughing, fever, vomiting, and potentially lethal organ failure. While some symptoms are caused by the pathogenic infection, others are caused by the immune system's efforts to kill the pathogen, such as ...