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  2. Timeline of peptic ulcer disease and Helicobacter pylori

    en.wikipedia.org/wiki/Timeline_of_peptic_ulcer...

    The European Helicobacter Pylori Study Group published the Maastricht 2-2000 Consensus Report, suggesting a "test-and-treat" strategy for H. pylori in young patients without atypical symptoms. This strategy advocates the use of noninvasive testing to evaluate for H. pylori and simply treating if found, even in the absence of ulcer disease ...

  3. Treatment and control groups - Wikipedia

    en.wikipedia.org/wiki/Treatment_and_control_groups

    A clinical control group can be a placebo arm or it can involve an old method used to address a clinical outcome when testing a new idea. For example in a study released by the British Medical Journal, in 1995 studying the effects of strict blood pressure control versus more relaxed blood pressure control in diabetic patients, the clinical control group was the diabetic patients that did not ...

  4. Clinical study design - Wikipedia

    en.wikipedia.org/wiki/Clinical_study_design

    Randomized controlled trial [5]. Blind trial [6]; Non-blind trial [7]; Adaptive clinical trial [8]. Platform Trials; Nonrandomized trial (quasi-experiment) [9]. Interrupted time series design [10] (measures on a sample or a series of samples from the same population are obtained several times before and after a manipulated event or a naturally occurring event) - considered a type of quasi ...

  5. Peptic ulcer disease - Wikipedia

    en.wikipedia.org/wiki/Peptic_ulcer_disease

    About 10% of people develop a peptic ulcer at some point in their life. [9] Peptic ulcers resulted in 267,500 deaths in 2015, down from 327,000 in 1990. [ 6 ] [ 10 ] The first description of a perforated peptic ulcer was in 1670, in Princess Henrietta of England . [ 2 ]

  6. Intention-to-treat analysis - Wikipedia

    en.wikipedia.org/wiki/Intention-to-treat_analysis

    In medicine an intention-to-treat (ITT) analysis of the results of a randomized controlled trial is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random attrition of participants from the ...

  7. Zelen's design - Wikipedia

    en.wikipedia.org/wiki/Zelen's_design

    Zelen's design is an experimental design for randomized clinical trials proposed by Harvard School of Public Health statistician Marvin Zelen (1927-2014). In this design, patients are randomized to either the treatment or control group before giving informed consent. Because the group to which a given patient is assigned is known, consent can ...

  8. N of 1 trial - Wikipedia

    en.wikipedia.org/wiki/N_of_1_trial

    An N of 1 trial (N=1) is a multiple crossover clinical trial, conducted in a single patient. [1] A trial in which random allocation is used to determine the order in which an experimental and a control intervention are given to a single patient is an N of 1 randomized controlled trial.

  9. Evidence-based nursing - Wikipedia

    en.wikipedia.org/wiki/Evidence-based_nursing

    Also, the study must be conducted using best available research methods. Question 2 measures the reliability of the study. If it is an intervention study, reliability consists of: whether the intervention worked, how large the effect was, and whether a clinician could repeat the study with similar results.