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The criteria included weight loss of at least 5% in 12 months or low body mass index (less than 22 kg/m 2) with at least three of the following features: decreased muscle strength, fatigue, anorexia, low fat-free mass index, or abnormal biochemistry (increased inflammatory markers, anemia, low serum albumin). [11]
Benign tumor growth causes a mass effect that can compress neighboring tissues. This can lead to nerve damage, blood flow reduction ( ischemia ), tissue death ( necrosis ), or organ damage. The health effects of benign tumor growth may be more prominent if the tumor is contained within an enclosed space such as the cranium , respiratory tract ...
By contrast, hypertrophy is what occurs, for example, to skeletal muscle cells during weight training and is simply an increase in the size of the cells. [12] With IGF use, one is able to cause hyperplasia which actually increases the number of muscle cells present in the tissue. [ 13 ]
Even 15% of adipose (fat) tissue is estimated to be made up of lean mass. Consequently, a considerable loss of adipose tissue is expected to be accompanied by a significant loss of fat-free mass ...
Cerebral cavernous malformation (CCM) is a cavernous hemangioma that arises in the central nervous system.It can be considered to be a variant of hemangioma, and is characterized by grossly large dilated blood vessels and large vascular channels, less well circumscribed, and more involved with deep structures, with a single layer of endothelium and an absence of neuronal tissue within the lesions.
Mutations in myostatin do more than just affect the amount of muscle mass an organism can produce; they also have variable effects on other phenotypes for different species. [21] For example, a Belgian Blue bovine with a mutation that inhibits myostatin production will exhibit a dramatic increase in muscle mass but will also lead to dystocia. [21]
Lipomas are rarely life-threatening, and the common subcutaneous lipomas are not a serious condition. Lipomas growing in internal organs can be more dangerous; for example, lipomas in the gastrointestinal tract can cause bleeding, ulceration, and painful obstructions (so-called "malignant by location", despite being a benign growth histologically).
Weight gain is an increase in body weight. This can involve an increase in muscle mass , fat deposits , excess fluids such as water or other factors. Weight gain can be a symptom of a serious medical condition.