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While generally considered safe overall for managing diabetes, the safety of a medication during pregnancy calls for a different review. Details on the study of metformin vs. insulin during pregnancy
Another review found good short term safety for both the mother and baby with metformin but unclear long term safety. [93] People may prefer metformin by mouth to insulin injections. [3] Treatment of polycystic ovarian syndrome with metformin during pregnancy has been noted to decrease GDM levels. [94]
A total review of metformin use during pregnancy compared to insulin alone found good short-term safety for both the mother and baby, but safety in the longer term is unclear. [61] Several observational studies and randomized controlled trials found metformin to be as effective and safe as insulin for the management of gestational diabetes.
To put it simply, metformin decreases glucose (aka blood sugar) output by the liver and improves insulin sensitivity in muscle and liver, which helps lower blood sugar values, says Deena Adimoolam ...
Generally speaking, GLP-1s, GIP/GLP-1s, and metformin are considered safe and effective when used as prescribed. That said, no medication is without side effects.
Metformin treatment in pregnancy is not safe. [91] In 2007, the Royal College of Obstetricians and Gynaecologists also recommended against the use of the drug to prevent miscarriage. [ 90 ] Thrombophilias or defects in coagulation and bleeding were once thought to be a risk of miscarriage but have been subsequently questioned. [ 92 ]
As with anything pregnancy-related, speaking to a healthcare provider is your best bet. They can assess your situation and explain your choices to help you find the best treatment plan.
It was found that Acarbose appeared to reduce incidence of diabetes mellitus type 2 when compared to placebo, however there was no conclusive evidence that acarbose compare to diet and exercise, metformin, placebo, no intervention improved all-cause mortality, reducer or increased risk of cardiovascular mortality, serious or non-serious adverse ...