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In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy. And there is an indication that phosphonate derivatives are "promising ligands for nuclear medicine." [2]
With the formula (HO) 2 P(O)CH 2 NHCH 2 CO 2 H, this derivative of glycine is one of the most widely used herbicides. Bisphosphonates are a class of drugs to treat osteoporosis. The nerve gas agent sarin, containing both C–P and F–P bonds, is a phosphonate. [citation needed] Phosphinates feature two P–C bonds, with the general formula R 2 ...
Although they are derivatives of phosphonous acid (RP(OH) 2), [2] they are not prepared from such precursors. Phosphonites are prepared by alcoholysis of organophosphinous chlorides. For example, treatment of dichlorophenylphosphine with methanol and base gives dimethyl phenylphosphonite:
Phosphonate esters (18 P) Pages in category "Phosphonates" The following 6 pages are in this category, out of 6 total. This list may not reflect recent changes. *
This nomenclature is commonly reserved for substituted derivatives, that is, organic group bonded to phosphorus, not simply an ester. For example, (CH 3 )PO(OH) 2 is " methylphosphonic acid ", which may of course form "methyl phosphonate " esters .
Glyphosate is a derivative of aminophosphonic acid and the amino acid glycine. Both the phosphonic acid and carboxylic acid moieties can ionised (deprotonated) and the amine group can be protonated. Consequently the substance exists as a series of rapidly interchanging zwitterions.
Diorganophosphites are derivatives of phosphorus(V) and can be viewed as the di-esters of phosphorous acid ((HO) 2 P(O)H). They exhibit tautomerism , however, the equilibrium overwhelmingly favours the right-hand (phosphonate-like) form: [ 11 ] [ 12 ]
The insecticide fosthietan is a phosphoramidate. In organophosphorus chemistry, phosphoramidates (sometimes also called amidophosphates) are a class of phosphorus compounds structurally related to phosphates (or organophosphates) via the substitution of an −O − group for an amine group (−N−).