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Dupuytren's contracture of the right little finger. Arrow marks the area of scarring. Typically, Dupuytren's contracture first presents as a thickening or nodule in the palm, which initially can be with or without pain. [12] Later in the disease process, which can be years later, [13] there is increasing loss of range of motion of the affected ...
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen.It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous ...
In adjunct with surgery, refractory muscle contracture can also be treated with Botulinum toxins A and B; however, the effectiveness of the toxin is slowly lost over time, and most patients need a single treatment to correct muscle contracture over the first few weeks after surgery. [21] Shortening of the surgically lengthened muscle can re-occur.
Treatment is mainly surgical; radiotherapy or chemotherapy is usually an indication of relapse. [clarification needed] Head and neck desmoid fibromatosis is a serious condition due to local aggression, specific anatomical patterns and the high rate of relapse. For children surgery is particularly difficult, given the potential for growth disorders.
The causes of some deformities, such as Dupuytren's contracture, are difficult to determine exactly, however chances of developing the deformity may be increased by certain chronic behaviours or disease. [3] Consequences can be similar to trauma related ones, in that joint use may be disrupted. [20]
Dupuytren's contracture Guillaume Dupuytren, Baron Dupuytren ( UK : / ˌ dj uː p w iː ˈ t r æ̃ , dj uː ˈ p w iː t r ɛ n / , [ 1 ] US : / d ə p w iː ˈ t r æ̃ , d ə ˈ p w iː t r ən / , [ 2 ] French: [ɡijom dypɥitʁɛ̃] ; 5 October 1777 – 8 February 1835) was a French anatomist and military surgeon .
In pathology, a contracture is a shortening of muscles, tendons, skin, and nearby soft tissues that causes the joints to shorten and become very stiff, preventing normal movement. [ 1 ] [ 2 ] A contracture is usually permanent, but less commonly can be temporary (such as in McArdle disease ), [ 3 ] or resolve over time but reoccur later in life ...
Dupuytren's contracture A condition that causes the fingers to curve inward and may also affect the palm. The condition is more common in people with diabetes and may precede diabetes. The mechanism is unclear. Treatment is limited to surgery (typically only in severe cases) and is usually of limited value. Dysglycemia (or dysglycaemia)