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Kidney ischemia is a loss of blood flow to the kidney cells. Several physical symptoms include shrinkage of one or both kidneys, [19] renovascular hypertension, [20] acute renal failure, [19] progressive azotemia, [19] and acute pulmonary edema. [19] It is a disease with high mortality rate and high morbidity. [21]
Despite the term posterior, this form of damage to the eye's optic nerve due to poor blood flow also includes cases where the cause of inadequate blood flow to the nerve is anterior, as the condition describes a particular mechanism of visual loss as much as the location of damage in the optic nerve.
A major risk factor for glaucoma is increased pressure within the eye, known as intraocular pressure (IOP). [1] It is associated with old age, a family history of glaucoma, and certain medical conditions or the use of some medications. [6] The word glaucoma comes from the Ancient Greek word γλαυκός (glaukós), meaning 'gleaming, blue ...
Pentoxifylline has been shown to reduce erythrocyte rigidity, resulting in decreased blood viscosity and increased flow velocity. [23] Animal studies have demonstrated that pentoxifylline can inhibit TNF and, in turn, prevent retinal ganglion cell death and axonal degeneration associated with optic neuropathy in a dose-dependent manner.
[2] [4] Restricted blood flow due to strokes reduces oxygen and glucose delivery to the brain, causing cell injury and neurological deficits in the affected region. [6] Subtypes of vascular dementia include subcortical vascular dementia, multi-infarct dementia, stroke-related dementia, and mixed dementia. [2] [5]
Ischemic optic neuropathies are classified based on the location of the damage and the cause of reduced blood flow if known. [3] Anterior ischemic optic neuropathy (AION) includes diseases that affect the optic nerve head and cause swelling of the optic disc. These diseases often cause sudden rapid visual loss in one eye.
Cotton wool spots are also associated with giant cell arteritis (GCA), a type of inflammation of the lining of the arteries, as this may reduce blood flow to the eyes. [1] In a study of 123 subjects with vision loss due to early stage giant cell arteritis, one-third of subjects had cotton wool spots present in their eyes. [ 2 ]
Carotid artery dissection is a serious condition in which a tear forms in one of the two main carotid arteries in the neck, allowing blood to enter the artery wall and separate its layers (*dissection*). This separation can lead to the formation of a blood clot, narrowing of the artery, and restricted blood flow to the brain, potentially ...