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Space-filling model of the PTEN protein (blue) complexed with tartaric acid (brown) [5] Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.
The enzyme phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) catalyzes the chemical reaction. 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H 2 O = 1-phosphatidyl-1D-myoinositol 4,5-bisphosphate + phosphate. This enzyme class belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.
It is associated with mutations in PTEN on 10q23.3, a tumor suppressor gene otherwise known as phosphatase and tensin homolog, that results in dysregulation of the mTOR pathway leading to errors in cell proliferation, cell cycling, and apoptosis. [5]
PtdIns(3,4,5)P 3 is dephosphorylated by the phosphatase PTEN on the 3 position, generating PI(4,5)P 2, and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring, producing PI(3,4)P 2. [5] The PH domain in a number of proteins binds to PtdIns(3,4,5)P 3. Such proteins include Akt/PKB, [6] PDPK1, [7] Btk1, and ARNO ...
The PAC-MANN test was able to differentiate — 98% of the time — between the blood of someone with pancreatic cancer and the blood of someone who doesn’t have the disease. When used alongside ...
In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate , it is a subcategory of hydrolases . [ 1 ]
PTEN inhibitors, such as bisperoxovanadium, [35] can enhance the PI3K/AKT pathway to promote cell migration, [36] survival [37] and proliferation. [7] While there are some concerns over possible cell cycle dysregulation and tumorigenesis, temporary and moderate PTEN inhibition may confer neuroprotection against traumatic brain injury [ 38 ] and ...
The enzyme phosphatidylinositol-3-phosphatase (EC 3.1.3.64) catalyzes the reaction 1-phosphatidyl-1D-myo-inositol 3-phosphate + H 2 O 1-phosphatidyl-1D-myo-inositol + phosphate. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.