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Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), [a] is a type of chronic liver disease. This condition is diagnosed when there is excessive fat build-up in the liver ( hepatic steatosis ), and at least one metabolic risk factor.
Fatty liver (FL) is commonly associated with metabolic syndrome (diabetes, hypertension, obesity, and dyslipidemia), but can also be due to any one of many causes: [14] [15] Alcohol Alcohol use disorder is one of the causes of fatty liver due to production of toxic metabolites like aldehydes during metabolism of alcohol in the liver. This ...
Between 25% and 58% of Americans have a fatty liver disease— a dietitian ... the diagnostic criteria for the two diseases overlap by 99%, so people who have NAFLD tend to also meet the criteria ...
Steatohepatitis is a type of fatty liver disease, characterized by inflammation of the liver with concurrent fat accumulation in liver. Mere deposition of fat in the liver is termed steatosis, and together these constitute fatty liver changes. [1] There are 2 main types of fatty liver disease (FLD):
Nonalcoholic fatty liver disease is a common but often overlooked condition affecting 1 in 4 Americans. It results from fat buildup in the liver, which can lead to inflammation, scarring, and ...
Liver enlargement (alcohol, NAFLD, haemochromatosis) Kayser-Fleisher rings (Wilson's disease) Increased pigmentation of the skin (haemochromatosis) Signs of right heart failure; Note that other diseases can involve the liver and cause hepatomegaly but would not be considered part of the spectrum of chronic liver disease.
Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged heavy alcohol use. It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinemia (excessive blood lipoprotein), jaundice (elevation of unconjugated bilirubin), and abdominal pain. [1]
Treatment of hepatomegaly varies with the cause, so accurate diagnosis is the first concern. In auto-immune liver disease, prednisone and azathioprine may be used for treatment. [3] In lymphoma the treatment options include single-agent (or multi-agent) chemotherapy and regional radiotherapy, and surgery is an option in specific situations.
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