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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
The US label for sodium oxybate has a black box warning because it is a central nervous system depressant (CNS depressant) and for its potential for abuse.Other potential adverse side effects include respiratory depression, seizures, coma, and death, especially when it is taken in combination with other CNS depressants such as alcohol.
Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...
Adjustment sleep disorder (acute insomnia) 307.41 F 51.02 Psychophysiological insomnia 307.42 F 51.04 Paradoxical insomnia (formerly sleep state misperception) 307.42 F 51.03 Idiopathic insomnia 307.42 F 51.01 Insomnia due to mental disorder 307.42 F 51.05 Inadequate sleep hygiene V69.4 Z72.821 Behavioral insomnia of childhood 307.42 —
Sleep diary layout example. Sleep medicine is a medical specialty or subspecialty devoted to the diagnosis and therapy of sleep disturbances and disorders. [1] From the middle of the 20th century, research has provided increasing knowledge of, and answered many questions about, sleep–wake functioning. [2]
Firazorexton was studied by Takeda for the treatment of narcolepsy. [3] [4] [5] It is a small-molecule and orally active compound and acts as a highly selective agonist of the orexin receptor 2 (OX 2) with >700-fold selectivity over the orexin receptor 1 (OX 1). [3] [4] [6] [7] Firazorexton is related to danavorexton (TAK-925). [8]
Dynamic steering response (DSR) is a vehicle safety and advanced power steering system that can counteract unstable or difficult steering that may be caused by external forces such as strong crosswinds or uneven roads by giving proper steering assistance from the steering gear. [1]
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