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As Izzie Stevens (Katherine Heigl) comes to terms with her Stage 4 metastatic melanoma diagnosis, she begins to refuse treatment, insisting she doesn’t want to fight the brain tumor. Cristina Yang ( Sandra Oh ), desperate to help Izzie, tries to convince her to reconsider, but her focus on Izzie starts affecting her own surgical performance.
Izzie's presence continues to influence Alex throughout later seasons, particularly in his relationship with Jo Wilson (Camilla Luddington). In the Season 12, "I Choose You", Jo discovers an invoice from the fertility clinic that stored the embryos created when Izzie had cancer, sparking questions about whether Alex might have children with ...
In an attempt to reason with Meredith, Derek makes her an offer: if she lets him report Webber, he will use his influence to get Izzie reinstated at the hospital once he takes over as Chief. Stevens returns to the hospital for a positron emission tomography (PET) scan, and it is revealed that her cancer is now in remission. Ecstatic, she shares ...
Meanwhile, George O'Malley (T. R. Knight) feels betrayed by Izzie Stevens (Katherine Heigl) for not informing him about her cancer diagnosis. In an effort to distract himself, he requests to work with Callie for the day, avoiding his emotional turmoil.
Izzie Stevens (Katherine Heigl) returns to work full-time, despite still recovering from her cancer treatment, wearing an auburn wig to conceal her hair loss. Lexie Grey ( Chyler Leigh ) is tasked with transferring blood to the OR for a trauma patient but slips while rushing through the hospital.
The episode centers around Cristina Yang , Alex Karev (Justin Chambers), George O'Malley (T. R. Knight), and Meredith Grey (Ellen Pompeo), who are anxiously waiting for Izzie Stevens (Katherine Heigl) to wake up after her surgery to treat cancer. Meanwhile, Derek Shepherd (Patrick Dempsey) develops an alternative treatment plan for Izzie.
The episode opens to a voice-over by Izzie Stevens (Katherine Heigl) about how life's biggest moments often come unexpectedly, shaping one's lives in profound ways. Izzie is excited about the wedding of Meredith Grey (Ellen Pompeo) and Derek Shepherd (Patrick Dempsey), which she prepared and will take place at the end of the day. Stevens, who ...
Where available, ICD-10 codes are listed. When codes are available both as a sign/symptom (R code) and as an underlying condition, the code for the sign is used. When there is no symptoms for a disease that a patient has, the patient is said to be asymptomatic.