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The pyrazole ring is found within a variety of pesticides as fungicides, insecticides and herbicides, [16] including fenpyroximate, fipronil, tebufenpyrad and tolfenpyrad. [18] Pyrazole moieties are listed among the highly used ring systems for small molecule drugs by the US FDA [ 19 ]
In 2004, a follow-up study described the PBP pyrrole ring as derived from L-proline. [11] This work involved an isotope-feeding study involving 21 different Alteromonas luteoviolaceus culture medias that were introduced with labeled [5-13 C]proline in addition to tyrosine, histidine, ornithine, glycine, potassium bromide (KBr), and PBP. From ...
Cannabicyclohexanol (CCH, CP 47,497 dimethyloctyl homologue, (C8)-CP 47,497) is a cannabinoid receptor agonist drug, developed by Pfizer in 1979. On 19 January 2009, the University of Freiburg in Germany announced that an analog of CP 47,497 was the main active ingredient in the herbal incense product Spice, specifically the 1,1-dimethyloctyl homologue of CP 47,497, which is now known as ...
The study of organic heterocyclic chemistry focuses especially on organic unsaturated derivatives, and the preponderance of work and applications involves unstrained organic 5- and 6-membered rings. Included are pyridine, thiophene, pyrrole, and furan. Another large class of organic heterocycles refers to those fused to benzene rings.
The lamellarins all contain a central pyrrole ring, substituted at the 3 and 4 positions by polyhydroxy- or methoxyphenyls. They are divided into two groups, depending on whether the pyrrole ring is fused or unfused.
Tetrapyrroles are a class of chemical compounds that contain four pyrrole or pyrrole-like rings. The pyrrole/pyrrole derivatives are linked by (= (CH)-or -CH 2-units), in either a linear or a cyclic fashion. Pyrroles are a five-atom ring with four carbon atoms and one nitrogen atom.
It is found in many drugs such as procyclidine and bepridil. It also forms the basis for the racetam compounds (e.g. piracetam, aniracetam). The amino acids proline and hydroxyproline are, in a structural sense, derivatives of pyrrolidine. Nicotine contains an N-methylpyrrolidine ring linked to a pyridine ring.
Zomepirac is the sodium salt of 5-(4-chlorobenzoyl)-1,4 dimethyl-1H-pyrrole-2-acetate dihydrate. It is a pyrrole - acetic acid which is structurally related to tolmetin . The chemical structure differs from other NSAIDs in that the central benzene ring has been replaced by a pyrrole.