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Finger tip carboxyhemoglobin saturation monitor.. A CO-oximeter is a device that measures the oxygen carrying state of hemoglobin in a blood specimen, including oxygen-carrying hemoglobin (O2Hb), non-oxygen-carrying but normal hemoglobin (HHb) (formerly, but incorrectly, referred to as 'reduced' hemoglobin), as well as the dyshemoglobins such as carboxyhemoglobin (COHb) and methemoglobin (MetHb).
The average red blood cell contains 250 million hemoglobin molecules. [7] Hemoglobin contains a globin protein unit with four prosthetic heme groups (hence the name heme-o-globin); each heme is capable of reversibly binding with one gaseous molecule (oxygen, carbon monoxide, cyanide, etc.), [8] therefore a typical red blood cell may carry up to one billion gas molecules.
The definitive test would be obtaining either CO-oximeter or a methemoglobin level on an arterial blood gas test. [3] Arterial blood with an elevated methemoglobin level has a characteristic chocolate-brown color as compared to normal bright red oxygen-containing arterial blood; the color can be compared with reference charts. [6]
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The functional oxygen saturation measured by this procedure is the basis for calibrating pulse oximeters. Pulse oximeters cannot be calibrated using physical procedures, but only by directly comparing the reported measurements and the parallel arterial oxygen saturation measured by hemoximetry in a group of healthy subjects. [citation needed]
An arterial blood gas (ABG) test, or arterial blood gas analysis (ABGA) measures the amounts of arterial gases, such as oxygen and carbon dioxide. An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle , [ 1 ] but sometimes the femoral artery in the groin or another site is used.
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