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The phrase "drug design" is similar to ligand design (i.e., design of a molecule that will bind tightly to its target). [6] Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, and side effects, that first must be optimized before a ligand can become a safe and effictive drug.
The importance of this field is reviewed in a book dedicated to the subject (Bodor, N.; Buchwald, P.; Retrometabolic Drug Design and Targeting, 1st ed., Wiley & Sons, 2012), as well as by a full chapter of Burger's Medicinal Chemistry and Drug Design, 7th ed. (2010) with close to 150 chemical structures and more than 450 references. [35]
Another method for drug discovery is de novo drug design, in which a prediction is made of the sorts of chemicals that might (e.g.) fit into an active site of the target enzyme. For example, virtual screening and computer-aided drug design are often used to identify new chemical moieties that may interact with a target protein.
Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. [ 1 ]
The God Hypothesis: Discovering Design in Our Just Right Goldilocks Universe. Rowman & Littlefield Publishers. ISBN 0-7425-5889-4; Paul Davies (2007). Cosmic Jackpot The Goldilocks Enigma: Why is the Universe Just Right for Life?. ISBN 978-0-618-59226-5; James Le Fanu (2009). Why Us?: How Science Rediscovered the Mystery of Ourselves. Pantheon.
Carl Wilhelm Scheele (German:, Swedish: [ˈɧêːlɛ]; 9 December 1742 – 21 May 1786 [2]) was a German Swedish [3] pharmaceutical chemist.. Scheele discovered oxygen (although Joseph Priestley published his findings first), and identified molybdenum, tungsten, barium, nitrogen, and chlorine, among others.
She is the author of a seminal volume in cheminformatics, Quantitative Drug Design (2nd Ed., 2010), and has been the recipient of numerous awards in her field, including being named as a fellow of the American Association for the Advancement of Science (1985) and of the International Union of Pure and Applied Chemistry (2000), and receiving the ...
Perkin could not have chosen a better time or place for his discovery: England was the cradle of the Industrial Revolution, largely driven by advances in the production of textiles; the science of chemistry had advanced to the point where it could have a major impact on industrial processes; and coal tar, the major source of his raw material ...
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