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The STS enzyme (EC 3.1.6.2), also referred to as Arylsulfatase C, is expressed throughout the body, with highest expression in the skin, liver, lymph nodes, and placenta, and lower expression in breast tissue and brain [24] STS catalyzes the hydrolysis of sulfated steroids, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS), to ...
Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. [4] It is one of the most abundant circulating steroids in humans. [5] DHEA is produced in the adrenal glands, [6] the gonads, and the brain. [7]
Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. [1] It is the 3β- sulfate ester and a metabolite of dehydroepiandrosterone (DHEA) and circulates in far greater relative concentrations than DHEA. [ 2 ]
Scalp psoriasis is an inflammatory and chronic autoimmune disease and is a common cause of scalp scabs and discolored patches of skin on and around the scalp. It can also affect other parts of the ...
A congenital deficiency in the enzyme is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000 to 6,000 males. [7] [8] The excessive skin scaling and hyperkeratosis is caused by a lack of breakdown and thus accumulation of cholesterol sulfate, a steroid that stabilizes cell membranes and adds cohesion, in the outer layers of the skin.
Essentially, toasted skin syndrome can happen anywhere that skin is exposed to heat. "The typical location of the discoloration is the back of heating pads and the anterior thighs from a laptop ...
The specific skin surface bacteria responsible are mainly Staphylococcus and Corynebacterium species. [2] The androstane steroids dehydroepiandrosterone sulfate (DHEA-S) and androsterone sulfate have been detected in an extract of axillary hairs together with high concentrations of cholesterol.
Many people think it could be a coronavirus—like SARS-CoV-2, the virus that causes illness with Covid-19—or a new strain of influenza, Dr Russo said. “But it could be brand new,” he added.