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Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. [1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. The most common and most severe form is systemic lupus erythematosus.
Low platelet count (thrombocytopenia) and low white blood cell count may be due to the disease or a side effect of pharmacological treatment. People with SLE may have an association with antiphospholipid antibody syndrome [ 26 ] (a thrombotic disorder), wherein autoantibodies to phospholipids are present in their serum.
Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. [1] [2] It presents with red, painful, inflamed and coin-shaped patches of skin with a scaly and crusty appearance, most often on the scalp, cheeks, and ears.
T-cells are white blood cells that play a key role in the body’s immune response. The study arrived at its findings by comparing blood samples from 19 people with lupus to blood samples from ...
Acute cutaneous lupus erythematosus is a cutaneous condition characterized by a bilateral malar rash (also known as a "butterfly rash") and lesions that tend to be transient, and that follow sun exposure. [1] The acute form is distinct from chronic and subacute cutaneous lupus erythematosus, which may have different types of skin lesions. [2]
A malar rash (from Latin mala 'jaw, cheek-bone'), also called butterfly rash, [1] is a medical sign consisting of a characteristic form of facial rash. It is often seen in lupus erythematosus. More rarely, it is also seen in other diseases, such as pellagra, dermatomyositis, and Bloom syndrome. Many conditions can cause rashes with a similar ...
Cutaneous vasculitis is the most common type of vasulitis amongst those with systemic lupus erythematosus. [7] The clinical presentation is variable and can include superficial ulcerations, splinter hemorrhages, panniculitis, macules, erythema with necrosis or erythematous plaques, cutaneous infarction, livedo reticularis, bullous lesions of the extremities or urticaria lesions, papulonodular ...
Sort of along the same lines, patients can have autoantibodies against components of the blood, causing various hematologic disorders, for example they’ll get anemia if red blood cells are targeted, thrombocytopenia if platelets are targeted, and leukopenia if white blood cells or immune cells are targeted.