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N-Hydroxysuccinimide (NHS) is an organic compound with the formula (CH 2 CO) 2 NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis. It can be synthesized by heating succinic anhydride with hydroxylamine or hydroxylamine hydrochloride. [2]
The ester linkage is formed between the N-hydroxyphthalimide and a carboxylic acid by elimination of water, the coupling achieved with N,N′-dicyclohexylcarbodiimide (DCC). For peptide synthesis, the N-terminus of the growing peptide is protected with tert-butyloxycarbonyl while its C-terminus (Z–NH–CH(R)–COOH) is coupled to N ...
Enormous challenges are posed by the trend towards recycled materials paper as raw material (the so-called secondary fibers), the rapid increase in the volume of cardboard at the expense of printing paper, the growing speeds (> 120 km/h [15]) and production quantities (maximum daily capacity of a single machine >4,500 tons or >1.5 million tons ...
Common uses for this carbodiimide include peptide synthesis, protein crosslinking to nucleic acids, but also in the preparation of immunoconjugates. EDC is often used in combination with N-hydroxysuccinimide (NHS) for the immobilisation of large biomolecules. Recent work has also used EDC to assess the structure state of uracil nucleobases in RNA.
Chemical water analysis is carried out on water used in industrial processes, on waste-water stream, on rivers and stream, on rainfall and on the sea. [1] In all cases the results of the analysis provides information that can be used to make decisions or to provide re-assurance that conditions are as expected.
Such compounds are sizing agents in the paper industry. In this role, the anhydride is proposed to form an ester with the hydroxyl groups on the cellulose fibers. [ 8 ] Maleic anhydride undergoes a similar reaction with polyisobutylene to give polyisobutylenylsuccinic anhydride , a common building block chemical in the petroleum additives industry.
Ecoinformatics – research dedicated to the development and dissemination of technological tools that facilitate analysis and synthesis in ecology. Conservation and Resource Management – research focused on areas such as conservation biology and the explicit application of science to natural resource management and policy decision making.
Pentafluorophenyl (PFP) esters are chemical compounds with the generic formula RC(O)OC 6 F 5. They are active esters derived from pentafluorophenol (HOC 6 F 5 ). PFP esters are useful for attaching fluorophores such as fluorescein [ 1 ] or haptens [ 2 ] to primary amines in biomolecules.