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Oral solution bottle of dypirone in its packaging (Portuguese lettering) Metamizole or dipyrone is a painkiller, spasm reliever, and fever reliever drug. It is most commonly given by mouth or by intravenous infusion. [ 13 ][ 11 ][ 14 ] It belongs to the ampyrone sulfonate family of medicines and was patented in 1922.
Ketorolac, sold under the brand name Toradol among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain. [ 2 ][ 3 ] Specifically it is recommended for moderate to severe pain. [ 4 ] Recommended duration of treatment is less than six days, [ 3 ] and in Switzerland not more than seven days (parenterally two days). [ 5 ]
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. [6] [9] It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops.
Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat partial seizures and neuropathic pain. [7] [10] It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [11]
There is some evidence suggesting that, for some people, use of NSAIDs (or other anti-inflammatories) may contribute to the initiation of chronic pain. [51] Side effects are dose-dependent, and in many cases severe enough to pose the risk of ulcer perforation, upper gastrointestinal bleeding, and death, limiting the use of NSAID therapy.
[12] [13] Side effects of nausea and constipation are rarely severe enough to warrant stopping treatment. It is used for pain due to myocardial infarction and for labor pains. [12] However, concerns exist that morphine may increase mortality in the event of non ST elevation myocardial infarction. [29]
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 30 to 50 times more potent than heroin and 100 times more potent than morphine; [10] its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. [11][12] Fentanyl is also used as a sedative. [13]
Main article: List of side effects of tramadol. The most common adverse effects of tramadol include nausea, dizziness, dry mouth, indigestion, abdominal pain, vertigo, vomiting, constipation, drowsiness, and headache. [ 34 ][ 35 ] Other side effects may result from interactions with other medications.
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