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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
16p11.2 deletion syndrome is a rare genetic condition caused by microdeletion on the short arm of chromosome 16. Most affected individuals experience global developmental delay and intellectual disability, as well as childhood-onset obesity. [1] 16p11.2 deletion is estimated to account for approximately 1% of autism spectrum disorder cases. [3] [4]
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
The mechanism is due to maternal meiotic non-disjunction followed by mitotic loss of the paternal chromosome 15 after fertilization. The third cause for PWS is the disruption of the imprinting process on the paternally inherited chromosome 15 (epigenetic phenomena). This disruption is present in approximately 2–5% of affected individuals.
Obesity has been associated with an inflammatory state, which is chronic and low-grade inflammation, known as meta-inflammation. [ 6 ] [ 7 ] Meta-inflammation is subclinical meaning that while there is an increase in circulating pro-inflammatory factors, no clinical signs of inflammation , heat, pain, and redness, are seen with meta ...
Obesity risk factors can be genetic or environmental — the latter has to do with lifestyle choices and things you don’t have as much control over, like illness or work stress.
233107 Ensembl ENSG00000153885 ENSMUSG00000030499 UniProt Q96SI1 Q8K0E1 RefSeq (mRNA) NM_001129994 NM_001129995 NM_024076 NM_146188 NM_001360818 NM_001360820 RefSeq (protein) NP_001123466 NP_001123467 NP_076981 NP_666300 NP_001347747 NP_001347749 Location (UCSC) Chr 19: 33.8 – 33.82 Mb Chr 7: 34.34 – 34.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium channel ...
The NFC wild-card game between the Los Angeles Rams and Minnesota Vikings is being moved to Arizona, the NFL announced Thursday. The game remains scheduled for Monday at 5 p.m. PT, but will now be ...