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"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as anxiolytic, sedative, hypnotic, skeletal muscle relaxant, amnesic, and anticonvulsant effects. Variation in potency of certain effects may exist amongst individual ...
Midazolam is known to cause respiratory depression. In healthy humans, 0.15 mg/kg of midazolam may cause respiratory depression, which is postulated to be a central nervous system (CNS) effect. [48] When midazolam is administered in combination with fentanyl, the incidence of hypoxemia or apnea becomes more likely. [49]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Midazolam is the most commonly prescribed for this use because of its strong sedative actions and fast recovery time, as well as its water solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect.
Midazolam – It is a fast-acting and the most lipophilic of all benzodiazepine and rapidly crosses the blood–brain barrier. It is a gamma-aminobutyric acid (GABA) agonist. [9] Usual doses for midazolam are 1 mg to 2 mg where the older people receive smaller doses and obese people receive higher doses.
Not more than 1 milligram of difenoxin and not less than 25 micrograms of atropine sulfate per dosage unit. [3] 9278 ... Midazolam [20] 2837 Nimetazepam [10] 2834 ...
The most common standard conscious sedation technique for adults is intravenous sedation using Midazolam. This requires a needle to be put into a vein to deliver the medication; this is known as an IV cannula. [citation needed] Indications: [citation needed] Reduced dental anxiety and phobia; Traumatic or prolonged dental procedures
Buccal tablets offer many advantages over other solid dosage forms also intended for oral administration (e.g. enteric-coated tablets, chewable tablets, and capsules). Buccal tablets can be considered in patients who experience difficulty in swallowing, since these tablets are absorbed into the blood stream between the gum and cheek.
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