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Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve ...
[1] [2] saRNAs are typically 21 nucleotides in length with a 2 nucleotide overhang at the 3' end of each strand, the same structure as a typical siRNA. To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured ...
The use of these products can be hazardous to health, potentially causing acne, stretch marks, skin cancer, [101] hypertension, or diabetes, especially when the product contains hydroquinone, [102] mercury, cortisone, or vitamin A. [103] Allergic reactions or undesirable effects such as uneven hyperpigmentation or patchy depigmentation can also ...
Lotion and shampoo at the Banff Centre. Lotion is a low-viscosity topical preparation intended for application to the skin. By contrast, creams and gels have higher viscosity, typically due to lower water content. [1] [2] Lotions are applied to external skin with bare hands, a brush, a clean cloth, or cotton wool.
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Frequent hand washing can result in chronic damage termed irritant contact dermatitis which includes dryness, irritation, itching, and more seriously, cracking and bleeding. [10] Irritant contact dermatitis is very common among nurses, ranging from 25% to 55%, with as many as 85% relating a history of having skin problems. [ 10 ]
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCl) is a topical anesthetic discovered at Abbott Laboratories in 1953 [1] and used as an antipruritic.During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. [1]
Sloan's Liniment, right, was once a popular over-the-counter drug. Liniment (from Latin: linere, meaning "to anoint"), also called embrocation and heat rub, is a medicated topical preparation for application to the skin.
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