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The classical explanation of HPV involves inhibition of hypoxia-sensitive voltage-gated potassium channels in pulmonary artery smooth muscle cells leading to depolarization. [ 3 ] [ 4 ] This depolarization activates voltage-dependent calcium channels , which increases intracellular calcium and activates smooth muscle contractile machinery which ...
The cardiovascular system circulates about 5 liters of blood at a rate of approximately 6 L/m. [4] The pulmonary and the systemic circulations are the two parts of the vasculature. The pulmonary circulation system consists of the network of blood vessels from the right heart to the lungs and back to the left heart.
Vasomotion is the spontaneous oscillation in tone of blood vessel walls, independent of heart beat, innervation or respiration. [1] While vasomotion was first observed by Thomas Wharton Jones in 1852, the complete mechanisms responsible for its generation and its physiological importance remain to be elucidated.
Depolarization is essential to the function of many cells, communication between cells, and the overall physiology of an organism. Action potential in a neuron, showing depolarization, in which the cell's internal charge becomes less negative (more positive), and repolarization, where the internal charge returns to a more negative value.
The bronchial arteries supply blood to the bronchi and connective tissue of the lungs. They travel with and branch with the bronchi, ending about at the level of the respiratory bronchioles. They anastomose with the branches of the pulmonary arteries, and together, they supply the visceral pleura of the lung in the process.
The contractile function of vascular smooth muscle regulates the lumenal diameter of the small arteries-arterioles called resistance arteries, thereby contributing significantly to setting the level of blood pressure and blood flow to vascular beds. Smooth muscle contracts slowly and may maintain the contraction (tonically) for prolonged ...
“Analyzing vascular fingerprints on the retina across populations can help identify trends and risk factors associated with stroke.” Seventeen of the 29 indicators are density indicators.
Cardiac physiology or heart function is the study of healthy, unimpaired function of the heart: involving blood flow; myocardium structure; the electrical conduction system of the heart; the cardiac cycle and cardiac output and how these interact and depend on one another.