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It is discouraged now since it can bring dangerous side effects such as neuroleptic malignant syndrome. [3] Most people eventually need levodopa and later develop motor complications. [3] The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease.
This is primarily co-administered with L-DOPA to combat Parkinson's disease. Administration can prevent common side-effects, such as nausea and vomiting, as a result of interaction with D 2 receptors in the vomiting center (or cheomoreceptor trigger zone) located outside the blood–brain barrier .
Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. [6] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. [6]
Adverse Reactions - lists all side effects observed in all studies of the drug (as opposed to just the dangerous side effects which are separately listed in "Warnings" section) Use in specific populations (pregnancy, lactation (breast-feeding), females and males of reproductive potential, pediatric, geriatric)
COMT inhibitors are indicated for the treatment of Parkinson's disease in combination with levodopa and an aromatic L-amino acid decarboxylase inhibitor (e.g. carbidopa or benserazide). The therapeutic benefit of using a COMT inhibitor is based on its ability to prevent the methylation of levodopa to 3- O -methyldopa , thus increasing the ...
The side effects are predominantly collected from studies of Parkinson's disease, where dopamine agonists are commonly used as a first-line treatment with levodopa. [ 16 ] Dopamine agonists are divided into two subgroups or drug classes, first-generation and newer agents.
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